Phenylpropanoids and polyketides
Medchemexpress LLC Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 1 ML
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, inhibits Apoptosis, and improves insulin resistance and insulin sensitivity.
- Potent and orally active curcumin analog
- Inhibits lipid droplet formation
- Increases autophagy
- Inhibits apoptosis
- Improves insulin resistance and insulin sensitivity
- Decreases palmitic acid (PA)-induced SREBP1 expression levels in AML12 cells
- Ameliorates insulin resistance and hepatic steatosis in mice with high-fat diet-induced obesity
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 5 MG
Curcumin 5-8 is a potent and orally active natural curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance.
- Improves insulin sensitivity.
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 25 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Curcumin 5-8 also improves insulin resistance and insulin sensitivity. This product is for research use only and not sold to patients.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
- For research use only and not sold to patients.
Medchemexpress LLC MRL-494 (hydrochloride) | 2699937-04-5 | 98.6% | 10 MG
MRL-494 hydrochloride is an antibacterial agent and an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, making it effective against both Gram-positive and Gram-negative bacteria. This agent lethally disrupts the cytoplasmic membrane and inhibits outer membrane protein biogenesis by targeting BamA.
- Inhibits β-barrel assembly machine A (BamA)
- Effective against Gram-positive bacteria
- Effective against Gram-negative bacteria
- Disrupts cytoplasmic membrane
- Inhibits outer membrane protein biogenesis
- White to off-white solid
![Medchemexpress LLC Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester | 1439366-88-7 | 99.7% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231161.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-[(2R,3S)-2-methyl-4-oxo-3-oxetanyl]-, 5-phenylpentyl ester | 1439366-88-7 | 99.7% | 1 ML
ARN 077 (enantiomer) is the less-active stereoisomer of ARN 077 (also reported as URB913 enantiomer). It is supplied for research use and reported to inhibit rat NAAA with an IC50 of 3.53 μM for the less-active enantiomer. The compound is offered as a 10 mM solution in DMSO (1 mL) and as solid quantities for laboratory use.
- Supplied as 10 mM solution in DMSO, 1 mL, and as solids for flexibility in experiments.
- High reported purity (≈99.7%), suitable for research applications.
- Molecular formula C16H21NO4, molecular weight 291.34 g/mol.
- Reported CAS number 1439366-88-7 for unambiguous identification.
- Intended for research use only; not for human or diagnostic use.
TARGETMOL CHEMICALS INC Seviteronel R enantiomer 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Seviteronel R enantiomer (VT-464 R enantiomer) is a Seviteronel isomer produced during the manufacturing process. Purity 99.98%
Medchemexpress LLC Tyrphostin AG30 | 122520-79-0 | MFCD09739079 | 99.7% | 205.17 | C10H7NO4 | 1 ML
Tyrphostin AG30 (CAS 122520-79-0) is a small-molecule inhibitor of EGFR tyrosine kinase supplied as a 10 mM solution in DMSO (1 mL), intended for biochemical and cell-based research.
- Potent and selective EGFR tyrosine kinase inhibition.
- Supplied as a ready-to-use 10 mM solution in DMSO.
- High purity suitable for research applications.
- Molecular weight 205.17 and formula C10H7NO4 provided for characterization.
- Storage recommendations provided to maintain compound stability.
Chem-Impex International, Inc. Curcumin | 458-37-7 | MFCD00008365 | 25G
Curcumin, 458-37-7, MFCD00008365, 25G
![eMolecules Medchem Express / MRL-494 (hydrochloride) / 5mg / 552386588 / HY-128773A / / 2699937-04-5 / [null] / 659.130 / C26H36ClFN16O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502476283.JPG-250.jpg)
eMolecules Medchem Express / MRL-494 (hydrochloride) / 5mg / 552386588 / HY-128773A / / 2699937-04-5 / [null] / 659.130 / C26H36ClFN16O2
Medchem Express / MRL-494 (hydrochloride) / 5mg / 552386588 / HY-128773A / / 2699937-04-5 / [null] / 659.130 / C26H36ClFN16O2
Medchemexpress LLC Tyrphostin AG 1288 | 116313-73-6 | MFCD00236451 | 98.7% | 231.16 g/mol | C10H5N3O4 | 100 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used for research to probe kinase-mediated signaling. It inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro and is supplied as a light yellow solid with high purity for biochemical and cell-based studies.
- Potent tyrosine kinase inhibitor for research applications.
- Reported to inhibit ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- High purity (~98.7%) suitable for analytical and biological studies.
- Molecular weight 231.16 g/mol; formula C10H5N3O4.
- Stable as a powder with recommended cold storage for long-term integrity.
- Available in multiple milligram pack sizes for assay flexibility.
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | >98.0% | C19H20O2 | 10MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one (CAS 100667-52-5) is a diarylheptanoid research chemical used as a biochemical reagent for laboratory studies. It appears as a white to off-white solid and is characterized by molecular formula C19H20O2 and a molecular weight of 280.4 g/mol. The compound is provided in small research-scale quantities for analytical, assay, and synthetic applications.
- High purity (>98.0%).
- Accurate molecular formula C19H20O2.
- Suitable for assay and analytical use in research settings.
- Supplied in small milligram package sizes for laboratory workflows.
- Includes standard structural identifiers for cheminformatics (SMILES, InChIKey).
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Medchemexpress LLC Tyrphostin AG 879 | 148741-30-4 | 99.3% | 316.46 | 1 ML
Tyrphostin AG 879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, demonstrating at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 exhibits anticancer activity.
- Tyrosine kinase inhibitor.
- Inhibits TrKA phosphorylation (IC50 of 10 μM).
- Selective ErbB2 tyrosine kinase inhibitor (IC50 of 1 μM), with >500-fold selectivity over EGFR.
- Possesses anticancer activity.
- Significantly and dose-dependently decreases cell proliferation in various cell lines (e.g., HL-60, U-937, PC-3) in vitro.
- Induces a dose-dependent increase in apoptosis in several cell lines in vitro.
- Reduces tumor sizes in athymic, immunodepressed NOD/SCID female mice in vivo.